{"id":3541,"date":"2021-03-19T22:59:32","date_gmt":"2021-03-19T22:59:32","guid":{"rendered":"https:\/\/darachi.com\/?p=3541"},"modified":"2021-03-19T22:59:32","modified_gmt":"2021-03-19T22:59:32","slug":"vanden-bossche-theory-fact-or-fiction","status":"publish","type":"post","link":"https:\/\/darachi.com\/vanden-bossche-theory-fact-or-fiction\/","title":{"rendered":"Vanden Bossche&#8217;s Theory: Mass Vaccination Will Breed Dangerous Variants \u2013 Fact or Fiction?"},"content":{"rendered":"<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-3591\" src=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert-Vanden-Bossche_Theory_cover_1280.png\" alt=\"Geert Vanden Bossche Theory\" width=\"1280\" height=\"720\" srcset=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert-Vanden-Bossche_Theory_cover_1280.png 1280w, https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert-Vanden-Bossche_Theory_cover_1280-300x169.png 300w, https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert-Vanden-Bossche_Theory_cover_1280-1024x576.png 1024w, https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert-Vanden-Bossche_Theory_cover_1280-768x432.png 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/p>\n<h1>Background<\/h1>\n<p>The <a href=\"https:\/\/darachi.com\/geert-vanden-bossche-mass-vaccination-danger\/\" target=\"_blank\" rel=\"noopener\">two posts<\/a> I made regarding Vanden Bossche&#8217;s theory which claims mass vaccination is &#8220;transforming a quite <a href=\"https:\/\/darachi.com\/covid-ifr\/\" target=\"_blank\" rel=\"noopener\">harmless virus<\/a> into an uncontrollable monster&#8221; attracted a lot of interest. Naturally people were then eager to know if it had truth.<\/p>\n<p>I considered it having some degree of credibility, else I&#8217;d not have published it. However my cause is five-fold:<\/p>\n<blockquote><p><strong>Struggle to maintain the power or right to express one\u2019s opinions without censorship, restraint, or legal penalty. Second, the protection of sufficiently broad public discourse. Third, the protection of scientific discovery, a process which requires the free exchange of ideas. Fourth, provision of counterbalance to propaganda, namely biased or misleading information provided by mainstream media, typically in support of a political cause or point of view. Fifth, an extra voice for the more vulnerable in society; children, elderly, the sick and the poor.<\/strong><\/p><\/blockquote>\n<p>Once something seems to have a degree of credibility and it&#8217;s censored by big tech (or looks likely to be censored), I add it to a list for consideration of publication.<\/p>\n<p>Because of the interest expressed, I decided to have a first-round of validity scoring. I pinged three top-scientists, namely:<\/p>\n<ol>\n<li>Dr Byram Bridle, Viral Immunologist<\/li>\n<li>Dr Knut Wittkowski, Epidemiologist<\/li>\n<li>Dr Mike Yeadon, Former Vice President and Chief Science Officer for Pfizer<\/li>\n<\/ol>\n<p>And asked their thoughts in a few email exchanges.<\/p>\n<p>I&#8217;ve posted their raw unedited emails below, along with the biography of each.<\/p>\n<p>If there&#8217;s more interest, I&#8217;ll go to a round-two of validity scoring, taking into account the input below.<\/p>\n<div class=\"email-signup-wrapper\">\n  <div class=\"signup-title\"><span>\n    <svg width=\"36\" height=\"36\" viewBox=\"0 0 36 36\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n      <path d=\"M1.05469 36H34.9453C35.5278 36 36 35.5278 36 34.9453V13.7812C36 13.4408 35.8333 13.1267 35.5737 12.9342L29.6016 8.5043V5.34375C29.6016 4.76128 29.1293 4.28906 28.5469 4.28906H23.9812L18.6395 0.216C18.2618 -0.072 17.7382 -0.072 17.3605 0.216L12.0188 4.28906H7.45312C6.87066 4.28906 6.39844 4.76128 6.39844 5.34375V8.5043L0.426375 12.9342C0.159961 13.1313 0 13.4494 0 13.7812V34.9453C0 35.5278 0.472219 36 1.05469 36ZM29.6016 11.1307L33.1787 13.7841C32.3252 14.4213 31.0568 15.3683 29.6016 16.455V11.1307ZM18 2.38099L20.5024 4.28906H15.4976L18 2.38099ZM8.50781 6.39844H27.4922V18.03C23.793 20.7922 19.6485 23.8876 18 25.1202C16.3515 23.8876 12.207 20.7923 8.50781 18.03V6.39844ZM6.39844 11.1307V16.455C4.94318 15.3683 3.67481 14.4213 2.82129 13.784L6.39844 11.1307ZM2.10938 15.8849C6.17379 18.9196 16.2555 26.4475 17.3672 27.2812C17.7422 27.5625 18.2578 27.5625 18.6328 27.2812C19.7445 26.4475 29.8262 18.9196 33.8906 15.8849V33.8906H2.10938V15.8849Z\" fill=\"#00314E\"\/>\n      <path d=\"M11.0389 26.1212L6.11725 29.8124C5.65129 30.162 5.55679 30.823 5.90632 31.289C6.25408 31.7526 6.91467 31.8511 7.38288 31.4999L12.3045 27.8087C12.7705 27.4591 12.865 26.7981 12.5155 26.3321C12.166 25.8661 11.5049 25.7716 11.0389 26.1212Z\" fill=\"#00314E\"\/>\n      <path d=\"M29.8829 29.8124L24.9612 26.1212C24.4954 25.7716 23.8341 25.8661 23.4847 26.3321C23.1352 26.7981 23.2297 27.4591 23.6956 27.8087L28.6173 31.4999C29.0811 31.8478 29.7428 31.7571 30.0938 31.289C30.4434 30.823 30.3489 30.162 29.8829 29.8124Z\" fill=\"#00314E\"\/>\n      <path d=\"M13.7812 12.7266H22.2188C22.8012 12.7266 23.2734 12.2543 23.2734 11.6719C23.2734 11.0894 22.8012 10.6172 22.2188 10.6172H13.7812C13.1988 10.6172 12.7266 11.0894 12.7266 11.6719C12.7266 12.2543 13.1988 12.7266 13.7812 12.7266Z\" fill=\"#00314E\"\/>\n      <path d=\"M23.2734 15.8906C23.2734 15.3082 22.8012 14.8359 22.2188 14.8359H13.7812C13.1988 14.8359 12.7266 15.3082 12.7266 15.8906C12.7266 16.4731 13.1988 16.9453 13.7812 16.9453H22.2188C22.8012 16.9453 23.2734 16.4731 23.2734 15.8906Z\" fill=\"#00314E\"\/>\n    <\/svg>\n    <\/span> <b>Blog to Email<\/b>Join 7689 other subscribers <\/div>\n  <div id=\"signup-form\">\n    <form action=\"https:\/\/www.aweber.com\/scripts\/addlead.pl\" method=\"post\">\n      <input type=\"hidden\" name=\"listname\" value=\"awlist5858134\">\n      <input type=\"hidden\" name=\"meta_tags\" value=\"blog_post_signup_top\">\n      <input class=\"signup-email-input\" required=\"\" type=\"email\" placeholder=\"Your email address\" name=\"email\">\n      <button class=\"btn1\" style=\"transition:0.5s all\" type=\"submit\">Sign Up<\/button>\n    <\/form>\n  <\/div>\n  <div class=\"signup-foote\"> Information without censorship. One email, most days. No Spam. <\/div>\n<\/div>\n\n<h1 style=\"text-align: left;\">Dr Byram Bridle<\/h1>\n<h6 style=\"text-align: left;\">BIOGRAPHY<\/h6>\n<p><img loading=\"lazy\" class=\"size-full wp-image-1122 alignright\" src=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Byram_Bridle_Frame-300x253.png\" alt=\"Byram Bridle\" width=\"300\" height=\"253\" \/><\/p>\n<p>Dr. Byram Bridle is an Associate Professor of viral immunology at the University of Guelph. His research program focuses on the development and optimization of vaccines for the treatment of infectious diseases and cancers. In March of this year he and two of his colleagues were commissioned by the government of Ontario to engineer several potential vaccine candidates to provide protective immunity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is the causative agent of the coronavirus disease that emerged in 2019 (COVID-19).<\/p>\n<p>In collaboration with the National Microbiology Laboratory in Winnipeg, Manitoba, one of the vaccine candidates proved effective in protecting hamsters from COVID-19. This resulted in a contract being established with the National Research Council of Canada (NRC) to develop a manufacturing process for the vaccine. A second contract has been established with the NRC to advance a second-generation CVODI-19 vaccine into the translational research pipeline. Dr. Bridle has also co-authored a series of lay articles in The Conversation to provide information to the lay public about the immunological aspects of COVID-19 and the development of vaccines.<\/p>\n<h2 style=\"text-align: left;\">His thought<\/h2>\n<h6 style=\"text-align: left;\">EMAIL 1<\/h6>\n<p><span style=\"background-color: #e3edfd;\">Although Geert gets there by a slightly different route, we both end up at the same conclusion: that current design of the vaccines and the way they are being rolled out creates risk of the emergence of immunoevasive variants.<\/span><\/p>\n<h6 style=\"text-align: left;\">EMAIL 2<\/h6>\n<p><span style=\"background-color: #e3edfd;\">I don&#8217;t agree 100% with some of the minutiae of the scientific arguments,<\/span> but that is a moot point.<\/p>\n<p>I long ago drew a similar conclusion via a slightly different route through immunological and virological principles.<\/p>\n<p><span style=\"background-color: #e3edfd;\">In short, I agree with the big picture argument being made.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">I haven&#8217;t been so bold as to draw conclusions that are as &#8216;strong&#8217;, but I can&#8217;t disagree at all with Geert&#8217;s take-home message.<\/span><\/p>\n<p>He is a respected scientist and has published many papers in well-respected journals. <span style=\"background-color: #e3edfd;\">I can guarantee that he knows what he is talking about. I do think there is a high probability of our vaccine rollouts driving the emergence of dangerous variants.<\/span><\/p>\n<p>In fact, I just initiated intense communications with my local health unit because they have just started a series of vaccination clinics and are not following the protocols approved by Health Canada (our regulatory agency).<\/p>\n<p>In fact, Canada has unwisely chosen to be a &#8216;leader&#8217; in extending the interval between the two doses of the COVID-19 vaccines to four months! There is no precedent in the world and no empirical data to back-up the decision. It was based on epidemiological modeling that had to incorporate several &#8216;assumptions&#8217;. All they focused on was theoretical effects on the immune system. They failed to consider effects on the virus.<\/p>\n<p><span style=\"background-color: #e3edfd;\">Canada&#8217;s rationale is that it is better to get twice as many people with sub-optimal immunity for an extended period of time rather than maximal immunity in half the people. This is akin to having an outbreak of a dangerous bacterium but not enough antibiotics to go around.<\/span> If one were to choose to administer the antibiotics for half the recommended # of days but to twice as many people, most scientists would agree that this would be an ideal scenario to promote the emergence of dangerous antibiotic-resistant variants. Physicians tell their patients to complete their antibiotic regimen, even when they start feeling much better part way in. To cut the treatment short = potentiation of risk of driving antibiotic resistance.<\/p>\n<p>So why are we doing this in the context of SARS-CoV-2?!? <span style=\"background-color: #e3edfd;\">The vaccine rollouts are already being done in a way that will drive the emergence of what we call &#8216;antigenic variants&#8217;;<\/span> these are versions of the virus that have incorporated sufficient mutations to allow the target antigen (in this case, the spike protein) to change enough in structure as to become unrecognizable by the highly specific antibodies and T cells that were induced by the vaccines.<\/p>\n<p><span style=\"background-color: #e3edfd;\">Specifically, the vaccines are being rolled out very slowly and are being distributed here and there (i.e. in piecemeal fashion). This means that vaccinated people will be intermingling with unvaccinated individuals. The latter can serve as a reservoir in the which the virus will have lots of time to incorporate random mutations and &#8216;test&#8217; its ability to infect vaccinated people.<\/span> If the latter happens, it would be result of an immuno-evasive variant emerging.<\/p>\n<p>Adding unvalidated uses of the existing vaccines will only accelerate progress to this point. <span style=\"background-color: #e3edfd;\">If a variant emerges that can bypass the immunity conferred by all current vaccines, we will be back to &#8216;square one&#8217; and all our lockdowns for the past year will have been of zero net benefit.<\/span><\/p>\n<p>We already have clear evidence this can happen: the Novavax, Johnson &amp; Johnson, and AstraZeneca vaccines have all performed much poorer against the South African variant; AstraZeneca&#8217;s provides very little protection against it.<\/p>\n<p>An article that backs this concept of vaccines driving antigenic variation was accepted for publication two days ago:<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03398-2\" target=\"_blank\" rel=\"noopener\">Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7<\/a><\/p>\n<p>&#8230;here are some concerning quotes:<\/p>\n<blockquote><p>&#8220;The recent emergence of B.1.1.7, B.1.351, and P.1 marks the beginning of SARS-CoV-2 antigenic drift&#8221;; &#8220;If the rampant spread of the virus continues and more critical mutations accumulate, then we may be condemned to chasing after the evolving SARS-CoV-2 continually, as we have long done for influenza virus.&#8221;<\/p><\/blockquote>\n<p>With respect to this latter statement, <span style=\"background-color: #e3edfd;\">I have been convinced for a long time that SARS-CoV-2 will become endemic, just like influenza.<\/span> This is the precise reason why I have tried to advocate for &#8216;learning to live with the virus&#8217; since shortly after the pandemic began.<\/p>\n<p>Importantly, the authors of this paper conclude that the way to avoid this is to maximize immunity as quickly as possible. Indeed, if vaccines are used in this way, an outbreak can be stopped in its tracks and there would be insufficient time and reservoir populations would be too small to support emergence of variants.<\/p>\n<p>However, the authors are dreaming if they think our global vaccine rollout can be done in this proper way. It will never be fast enough. <span style=\"background-color: #e3edfd;\">Everything we are doing in the vaccine rollout, in fact, is potentiating the emergence of variants.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">It upsets me because public health officials are, in essence, driving the emergence of new variants that put you and me, and our families, friends and colleagues at risk of having to deal with potentially more dangerous version of this virus.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">Personally, I would like to have much broader immunity than what the current vaccines induce. Broader immunity = less chance that a variant can evade it (because they can&#8217;t change too many components and maintain fitness).<\/span><\/p>\n<p>By the way, the virology side of this is that coronaviruses naturally mutate over time. They employ an error-prone polymerase that randomly incorporates mutations when they copy their genetic material. This is a strategy that helps them adapt to new environmental pressures; such as narrowly-focused immunological pressure (and weak immunity caused by massive delays in administering second doses of vaccines).<\/p>\n<p>An additional note: Some have argued that the emergence of partially immunoevasive mutants of SARS-CoV-2 prior to the rollout of vaccines invalidates the idea of vaccines potentiating this effect. However, one could argue that this observation actually supports the idea. <span style=\"background-color: #e3edfd;\">The extended global lockdowns dramatically slowed progress towards natural immunity. Time and slow development of herd immunity = potentiation of immunoevasive mutants.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h1>Dr Knut Wittkowski<\/h1>\n<h6 style=\"text-align: left;\">BIOGRAPHY<\/h6>\n<p><img loading=\"lazy\" class=\"size-full wp-image-1122 alignright\" src=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Knut_Wittkowsk_Frame-300x254.png\" alt=\"Knut Wittkowski\" width=\"300\" height=\"253\" \/><\/p>\n<p>Dr. Wittkowski received his PhD in computer science from the University of Stuttgart and his ScD in Medical Biometry from the Eberhard Karls University of T\u00fcbingen, both Germany. He worked for 15 years with Klaus Dietz, a leading epidemiologist who coined the term \u201creproduction number\u201d, on the Epidemiology of HIV before. Around 1990, he was one of the few to predict that HIV would not spread among Caucasian heterosexuals. After teaching epidemiology at the University of Cairo and the American University of Beirut, he was for 20 years head of Biostatistics, Epidemiology, and Research Design at The Rockefeller University, New York.<\/p>\n<p>Dr. Wittkowski is currently the CEO of ASDERA LLC, a company discovering novel interventions against complex diseases from data of genome-wide association studies, including a nutritional intervention to reduce cellular support for virus replication and to improve cardiovascular and metabolic health as a natural strategy to reduce the burden and stop the continuation of the COVID epidemics.<\/p>\n<h2>His thought<\/h2>\n<h6>EMAIL 1<\/h6>\n<p><span style=\"background-color: #e3edfd;\">It\u2019s mitigation [e.g. lockdowns] that gives a virus more time. Vaccination is the opposite: it speeds up time to herd immunity.<\/span><\/p>\n<h6>EMAIL 2<\/h6>\n<p><span style=\"background-color: #e3edfd;\">I\u2019m trying to find some logic in his arguments, that would relate to what we know about epidemiology, but I can\u2019t.<\/span><\/p>\n<p>Vaccination speeds up the development of herd immunity by reducing the wait time until the same person gets infected naturally. Speeding up the buildup of HI [herd immunity] reduces the chance that a lineage will successively develop escape mutations against all antibodies generated by the polyclonal immune response and thereby become resistant.<\/p>\n<p><span style=\"background-color: #e3edfd;\">Hence, vaccination &#8211; if still effective when implemented &#8211; can be helpful, unless the politicians counteract the beneficial effect of vaccination (speeding up the development of HI) by mitigation (\u201cdistancing\u201d, lockdowns, curfews, &#8230; ), all of which prolong the time it takes to develop HI.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">One could argue that vaccines create fewer antibodies and, thus, increase the chance for shorter lineages to escape, but I can\u2019t find this argument in his writings.<\/span><\/p>\n<h6>EMAIL 3<\/h6>\n<p>In a <a href=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Geert_Vanden_Bossche_Scientific_Evidence_Final_March_13_2021.pdf\" target=\"_blank\" rel=\"noopener\">one-page summary<\/a> written by him, some of his basic flaws are much easier to find:<\/p>\n<blockquote><p>&#8220;Why is nobody worried about &#8216;immune escape&#8217; whereas Covid-19 has already escaped people&#8217;s innate immunity as reflected by multiple emerging, much more infectious, viral variants (most likely due to the global implementation of infection prevention measures)?&#8221;<\/p><\/blockquote>\n<p><span style=\"background-color: #e3edfd;\">In this sentence alone, he makes three fundamental mistakes:<\/span><\/p>\n<ol>\n<li>I am worried about immune escape, as are many other people, see Wang &#8230; Ho (2021, Nature). <span style=\"background-color: #e3edfd;\">The assumption that nobody is worried is wrong.<\/span><\/li>\n<li><span style=\"background-color: #e3edfd;\">The escape we see is not from innate immunity<\/span> (which are not specific to a particular pathogen), but from adaptive immunity (T-cells, antibodies, which are specific to a particular virus).<\/li>\n<li><span style=\"background-color: #e3edfd;\">I agree that the problem is &#8220;global implementation of infection prevention measures&#8221;, but the lockdowns are the problem, not the vaccines.<\/span> It is the lockdowns that are &#8220;transforming a quite harmless virus into an uncontrollable monster.&#8221;<\/li>\n<\/ol>\n<h6>EMAIL 4<\/h6>\n<p>I would replace [Geert&#8217;s claim of] \u201cresearch expert\u201d with \u201cresearch coordinator\u201d &#8211; \u201cI was a coordinator of the Ebola program at GAVI. So we were interacting with several different vaccine companies &#8230;&#8221;. Role of a coordinator.<\/p>\n<p>He is a PhD and DVM (veterinarian physician) not an MD.<\/p>\n<p><span style=\"background-color: #e3edfd;\">He is not \u201cboard certified\u201d in human virology or microbiology.<\/span><\/p>\n<p>\u201cSelf-limiting diseases\u201d &#8211; that\u2019s COVID.<\/p>\n<p>Viruses are not \u201cintracellular\u201d.<\/p>\n<p>COVID is not \u201cchronic\u201d (chicken pox and herpes are) SARS-CoV-2 gets cleared.<\/p>\n<p>Antibodies do not \u201ctranslate to the mucosa\u201d. The mucosa is where we have innate immunity.<\/p>\n<p>Viruses don\u2019t hide in cells, they get replicated in cells.<\/p>\n<p>Viruses don\u2019t \u201cfully escape to [sic] our antibody responses.\u201d We have neutralizing antibodies against viruses circulating in blood and we have non-neutralizing antibodies that direct killer T-cells to infected cells.<\/p>\n<p>I agree with \u201cit was a bad idea to do lockdowns that would also affect the younger people\u201d.<\/p>\n<p><span style=\"background-color: #e3edfd;\">The new \u201cCOVID strains\u201d are not so much more infectious that young people need to be afraid of them. Maybe a few more become (mostly) asymptomatically infected. That\u2019s it.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">A virus doesn\u2019t initially get \u201cto the folks that have &#8230; weak immunity\u201d. It infects everybody the same,<\/span> but those with \u201cweak immunity\u201d may have more severe symptoms.<\/p>\n<p>I agree that it would have been \u201cthe right thing to do, to protect [the elderly], and for them also to isolate, but &#8230; that is what we have not been doing.\u201d<\/p>\n<p>\u201cIf [young people] have quite decent innate immune response and therefore they are naturally protected &#8230; if they get in contact with coronavirus, it will boost their natural immunity.\u201d &#8211; you can\u2019t \u201cboost\u201d innate immunity.<\/p>\n<p>\u201cVulnerable people [have] no humoral immunity\u201d. Humoral immunity is the adaptive antibody mediated immunity. Except for newborns, everybody has it.<br \/>\nThe older you get, the more types of memory t-cells you have to make different types of antibodies.<\/p>\n<p><span style=\"background-color: #e3edfd;\">Innate immunity does not get \u201creplaced by antigen-specific &#8220;immunity as people get older.\u201d<\/span> Partly true, it becomes less important as we develop more antibodies. (Note that he is later arguing that vaccines weaken the innate immunity.)<\/p>\n<p>\u201cProphylactic vaccines should typically not be administered to people who are exposed to highly infectious pressure.\u201d ???<\/p>\n<p>\u201cWe are administering these vaccines in the heat of a pandemic &#8230; while &#8230; we are fully attacked by the virus\u201d. &#8211; So what? That\u2019s normal.<\/p>\n<p>Among \u201cpeople who get their first dose &#8230; the antibodies are not fully mature [sic], the titers are maybe not very high [that could be]. So their immune response is suboptimal [and] every single time you have an immune response that is suboptimal in the presence of an [infection\/virus] &#8230; you are at risk of immune escape.\u201d &#8211; Nonsense! &#8230; and then more nonsense.<\/p>\n<p><span style=\"background-color: #e3edfd;\">\u201cThese vaccines don\u2019t prevent infection\u201d &#8211; No vaccine does.<\/span><\/p>\n<p>&#8220;But in the meantime, &#8230; we give &#8230; by our interventions, the opportunity to escape to [sic] the immune system.\u201d &#8211; Correct, but this applies to the lockdowns, not the vaccinations.<\/p>\n<p>\u201cThe virus is not going to wait until we have those vaccines ready\u201d. &#8211; Correct, but this merely makes the vaccine ineffective.<\/p>\n<p><span style=\"background-color: #e3edfd;\">\u201c&#8230; antibiotics &#8230;\u201d are a bad example,<\/span> because antibiotics evolve in the patient (with mutations every couple of hours), viruses evolve in the population (with 1-2 mutations per month).<\/p>\n<h6>EMAIL 5<\/h6>\n<p>Since Geert Vanden Bossche is now pushing &#8220;natural antibodies\u201c I looked into this in a bit more detail, the term has been used by some Boyden (196..) and Ochsenbein (1999), and recently reviewed by Palma (2018) and Holodick (2017), but <span style=\"background-color: #e3edfd;\">it\u2018s nothing else than a subset of (mostly) IgM.<\/span> There are none of the potentials or dangers pushed by GvdB associated with it. Newborns have a lot of them as part of the innate immune system and children lose most of them as soon as they develop adaptive immunity (antibodies).<\/p>\n<p>It\u2018s still funny that somebody just created a more-or-less empty Wikipedia page for &#8220;natural antibodies\u201c and linked that page to &#8220;Antibodies\u201c.<\/p>\n<p>&nbsp;<\/p>\n<h1>Dr Mike Yeadon<\/h1>\n<h6 style=\"text-align: left;\">BIOGRAPHY<\/h6>\n<p><img loading=\"lazy\" class=\"size-full wp-image-1122 alignright\" src=\"https:\/\/darachi.com\/wp-content\/uploads\/2021\/03\/Mike_Yeadon_Frame-300x253.png\" alt=\"Mike Yeadon\" width=\"300\" height=\"253\" \/><\/p>\n<p>Dr Mike Yeadon is the former CSO and VP, Allergy and Respiratory Research Head with Pfizer Global R&amp;D. Following 32 years at Pfizer he co-founded biotech company Ziarco Pharma Ltd. which was acquired by pharma giant Novartis.<\/p>\n<p>Mike obtained a biological sciences Double First with Honours, and research based PhD in mechanisms of drug action.<\/p>\n<h2>His thought<\/h2>\n<h6>EMAIL 1<\/h6>\n<p><span style=\"background-color: #e3edfd;\">His article has little science in it but lots of claims, the basis of which I cannot understand. He appears to have completely ignored T-cell immunity.<\/span><\/p>\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.02.27.433180v1\" target=\"_blank\" rel=\"noopener\">Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266637912100015X\" target=\"_blank\" rel=\"noopener\">Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases<\/a><\/p>\n<p><span style=\"background-color: #e3edfd;\">In terms of immune escape, additional publications to me support the idea that it\u2019s extremely unlikely (whether that immunity is natural or due to vaccination).<\/span><\/p>\n<h6>EMAIL 2<\/h6>\n<p><span style=\"background-color: #e3edfd;\">No, I don\u2019t agree with him that vaccination at present will lead to escape variants.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">He chose not to address how it could be that variation could even begin to favour mutants which aren\u2019t recognised in part by the vast majority of short pieces of the virus which are not altered.<\/span><\/p>\n<p>Each individual uses a kind of combination lock, educating our T cells &amp; also our antibodies to recognise between 20 &amp; 40 separate protein snippets of the 10,000 amino acids that make up the virus.<\/p>\n<p>The most changed variants are less than 0.3% different from the original sequence from Wuhan. So these are 99.7% identical to the original. It\u2019s not possible that our bodies will not recognise every single variant as very close relatives of the original. No ones immune system will be fooled into thinking \u201cthis is a new virus, a new pathogen I\u2019ve not seen before\u201d.<\/p>\n<p>The most important thing to communicate is how unlikely it is to evade what\u2019s called \u201cmulti locus immunity\u201d. It would be, probabilistically, as if the virus rolled a dice &amp; got 20 sixes in a row (not quite, but this is the idea).<\/p>\n<p>But let\u2019s say it happened once. If there are enough replication events, maybe it will happen. Worst case is that individual may well be at risk, as if they had a suppressed immune system.<\/p>\n<p>Here\u2019s the reassuring part: because each of us uses a slightly different combination lock as we educate our immune systems through a kind of \u201cmolecular identity parade\u201d, checking responses to hundreds of different protein snippets.<\/p>\n<p>My selected set of 20-40 snippets which confers my immunity to this virus is DIFFERENT from the set of snippets another persons immune system is using.<br \/>\nSo even if there\u2019s an unlikely variant which escaped my combination lock immunity, it will not have escaped yours.<\/p>\n<p><span style=\"background-color: #e3edfd;\">Put plainly: I do not believe immune escape mutants are at all likely to have clinical consequences but the most important thing is that even if escape happened, it would represent a threat to an individual, NOT to the community.<\/span><\/p>\n<p>I do not understand how our Belgian colleague accommodates that concept, which has been demonstrated empirically in scores of convalescing people as well as those who\u2019s immunity was conferred through vaccination.<\/p>\n<p><span style=\"background-color: #e3edfd;\">But to finish on a positive note, I agree with his operational conclusion: do not vaccinate everybody.<\/span><\/p>\n<p><span style=\"background-color: #e3edfd;\">We have different rationales for our conclusions, but those recommendations are pleasingly convergent!<\/span><\/p>\n<div class=\"telegram-signup-wrapper\">\n  <div class=\"telegram-title\">Telegram<\/div>\n  <div id=\"telegram-button\">\n      <a href=\"https:\/\/t.me\/dryburgh\" target=\"_blank\">Join My Telegram Channel<\/a><\/button>\n  <\/div>\n  <div class=\"telegram-footer\"><a href=\"https:\/\/t.me\/dryburgh\" target=\"_blank\">t.me\/dryburgh<\/a><\/div>\n  <div class=\"telegram-logo-erapper\">\n  <img class=\"telegram-logo\" src=\"https:\/\/dryburgh.com\/wp-content\/themes\/dryburgh\/images\/telegram.svg\" alt=\"telegram\">\n<img class=\"telegram-tail\" src=\"https:\/\/dryburgh.com\/wp-content\/themes\/dryburgh\/images\/telegram-tail.svg\" alt=\"telegram\">\n  <\/div>\n<\/div>\n\n<p>&nbsp;<\/p>\n<p><strong>More Resources:<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/darachi.com\/geert-vanden-bossche-mass-vaccination-danger\/\" target=\"_blank\" rel=\"noopener\"><strong>Mass Vaccination will Breed Dangerous Variants &amp; Weaken Our Immunity \u2014 Geert Vanden Bossche, PhD<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/darachi.com\/vaccine-passport-battle\/\" target=\"_blank\" rel=\"noopener\"><strong>Vaccine Passports \u2014 Do You View The Battle Is Over And Lost? Or Just Starting?<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/darachi.com\/peter-doshi-is-corona-virus-vaccine-safe-bmj\/\" target=\"_blank\" rel=\"noopener\"><strong>Peter Doshi \u2014 Is the Coronavirus Vaccine Safe? We Don\u2019t Know Yet<\/strong><\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Background The two posts I made regarding Vanden Bossche&#8217;s theory which claims mass vaccination is &#8220;transforming a quite harmless virus into an uncontrollable monster&#8221; attracted a lot of interest. Naturally people were then eager to know if it had truth. I considered it having some degree of credibility, else I&#8217;d not have published it. However [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_mi_skip_tracking":false},"categories":[72],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mass Vaccination Will Breed Dangerous Variants \u2013 Fact or Fiction?<\/title>\n<meta name=\"description\" content=\"Vanden Bossche&#039;s theory is that mass vaccination will breed dangerous variants. 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